In addition, the KEGG and GO analyses of the single- cell RNA-seq dataset (GSE146771) suggested that increased expression of BST2 was strongly connected to the cell growth pathways such as the cell cycle and DNA replication pathways in CRC (Figure 5A-B), and immune response-related pathways such as the antigen processing and presentation pathway and activation of the immune response pathway were enriched in macrophages (Figure 5C-D). The gene discussed is BST2; the disease is colorectal carcinoma.