As a result of BLM stimulation, there was a dramatic decrease in Nrf2 protein value in the fibrosis lung tissues (vs control group, P<0.01), while the QFHXD-1239.9 mg/kg group markedly up-regulated the Nrf2 protein expression (vs fibrosis group, P<0.05,Figure 6B). This evidence concerns the gene NFE2L2 and fibrosis.