Furthermore, it reduced the increase in collagen deposition in the lung parenchyma, as it reduced the elevated levels of hydroxyproline in the lung tissue and the fibrosis score and restored the normal pulmonary collagen fiber distribution, as shown in Mallory’s trichrome stained sections and immunohistochemical expression of the lung parenchymal α-SMA. This evidence concerns the gene ACTA1 and fibrosis.