Therefore, vinpocetine was examined for its antifibrotic potentiality in the present study concerning its effect on rates of body weight gain, BALF total and differential cell count, cytokine levels, LDH, and lung tissue PDE activities, oxidative stress indicators, hydroxyproline content, histopathological changes, fibrosis score, and immunohistochemical expression α-SMA and macrophage CD68, in a rat model of PF induced by intratracheal administration of bleomycin. This evidence concerns the gene ACTA1 and pemphigus foliaceus.