IRS2 and cancer: Among them 6 genes (Irs2, Ptk2b, Pik3r1, Jun, Prkce, and Jak2) were thought to be oncogenes in the ONGene database; there is 190 cancer-related literature references for Jun and 15 for Jak2. SEPT9 methylated DNA test has been approved by FDA for colorectal cancer screening (54).