Among them 6 genes (Irs2, Ptk2b, Pik3r1, Jun, Prkce, and Jak2) were thought to be oncogenes in the ONGene database; there is 190 cancer-related literature references for Jun and 15 for Jak2. SEPT9 methylated DNA test has been approved by FDA for colorectal cancer screening (54). This evidence concerns the gene PIK3R1 and cancer.