And although we could demonstrate with flow cytometry sub-populations of PD-1+CD39+ T cells within MS normal-appearing and control WM, these were not enriched in MS lesions, did not express markers as CTLA-4, TIM-3, and LAG-3, and did not account for the increased proportion of cells not producing cytokines in MS lesions. This evidence concerns the gene LAG3 and myeloid sarcoma.