GAD1 and neurodevelopmental disorder: ,25,26 Similarly, upregulated genes were heavily enriched for neurogenic and neurodevelopmental processes (Figure 2A) with several genes implicated in neurodevelopmental disorders present in the top 18 upregulated DEGs (log2fc>1) including NR2F1,27SYT128 and GAD1. 29Thus, patterns of dysregulation in an organoid model of HNRNPU-related disorder are directionally consistent with an RNA-binding protein driven neurodevelopmental disorder.