KDM1A and Alzheimer disease: On the other hand, the CoREST complex is not recruited to its target loci without the REST scaffold 276, leading to an increase in H3K4me3 in the PFC of the AD brain due to a lack of demethylation catalyzed by LSD1 and its associated histone lysine demethylase 5A (KDM5A, an H3K4me3 demethylase) 279.