FOXP3 and autoimmune disease: Besides, Katoh et al. found that FOXP3, an X-linked suppressor of autoimmune diseases, increases both H4K16ac and H3K4me3 at multiple FOXP3-activated genes by recruiting MOF (which interacts with MLL1) and displacing histone H3K4 demethylase PLU-1 (KDM5B or JARID1B) 306, 307.