In silico analysis for its target prediction showed the binding capacity of miR-455-3p with several AD-associated key genes, such as APP, Nerve growth factor (NGF), Ubiquitin specific peptidase 25 (USP25), p53 and DNA damage regulated 1 (PDRG1), Small mothers against decapentaplegic member 4 (SMAD4), Ubiquilin 1 (UBQLN1), SMAD family member 2 (SMAD2), Tumor protein p73 (TP73), Vesicle associated membrane protein 2 (VAMP2), HSPB1 Associated Protein 1 (HSPBAP1), and Neurexin 1 (NRXN1) 391, 392. Here, SMAD2 is linked to Alzheimer disease.