Interestingly, many of these genes were previously shown to be AD susceptibility genes or connected to the AD susceptibility network and participate in different pathological processes of neurons or nonneuronal cells, such as amyloid pathology (APP, ABCA7, SERPINF1 and 2), tau pathology (BIN1), inflammation (ANK1, RHBDF2, IL-1β, and IL-6), protein dyshomeostasis (RPL13 and HOXA3), calcium dyshomeostasis (S100B), and cellular skeleton defects (MAP2 and MCF2L) 164-167. The gene discussed is BIN1; the disease is Alzheimer disease.