SSTR2 and neoplasm: The objectives of this study are (i) to establish an appropriate dose regimen for epigenetic treatment with VPA and DAC allowing for inducing both SSTR2 levels and uptake of SSTR2 radiotracers, such as [68Ga]Ga- and [64Cu]-Cu-DOTA-TATE, in MPC and MTT cells, (ii) to evaluate the effects of epigenetic treatment on tumor uptake of SSTR2 radiotracers in MPC and MTT allograft mice, and (iii) to characterize combination effects of epigenetic drugs and [177Lu]Lu-DOTA-TATE on growth response and gene expression of MPC and MTT tumors.