Further crystal structure analysis showed that the N-linked glycol chains of N32 and N55 of hCD47 contributed to the binding of 6MW3211-CD47 Fab (Figure 2G-H), which indicates that the selectivity of 6MW3211-CD47 binding to CD47 expressing on tumor cells may be due to the difference of N-linked glycosylation at position N32 and N55 between tumor cells and RBCs. The gene discussed is CD47; the disease is neoplasm.