CA9 and neoplasm: Experimental results demonstrated that Zr-MOF-QU could effectively inhibit the catalytic activity of carbonic anhydrase IX (CA IX) through the association of BDC decomposed from Zr-MOF-QU and the Zn2+ of CA IX in the TME, which was beneficial to alleviate the hypoxia-induced resistance at tumor sites, improving the RT therapeutic effect of the tumor.