Importantly, while in healthy tissue no signal from (m)anti-MMR Nbs was detected upon the administration of un-(biv)anti-MMR Nbs, in the tumor the presence of un-(biv)anti-MMR Nbs still allowed (m)anti-MMR Nbs to target TAMs (y'=|11.8424 e(-0.009512 x)|), albeit with a delayed kinetics and an overall lower fluorescence signal (Figure 4G, Table 2). Here, MRC1 is linked to neoplasm.