To confirm the MMR-specificity of (m)-anti-MMR Nbs within tumors, we stained the tumor and healthy tissues ex vivo with a conventional anti-MMR monoclonal antibody, demonstrating a colocalization of the in vivo staining (with (m)-anti-MMR Nbs) and ex vivo staining (with anti-MMR mAb) in healthy and neoplastic tissues (Figure 5E). This evidence concerns the gene MRC1 and neoplasm.