MRC1 and neoplasm: This observation suggests that, due to their differences in tissue diffusion capacity and avidity for the target, (biv)anti-MMR Nbs and (m)anti-MMR Nbs occupy different MMR+ TAM populations, with (biv)anti-MMR Nbs targeting the perivascular tumor regions and likely forcing the (m)anti-MMR Nbs to diffuse further into the tumor tissue and bind MMR+ TAMs in less accessible regions.