To this end, healthy mice or 3 weeks tumor-bearing mice were injected with FITC-dextran to visualize the tissue vasculature and, approximately 20 s after the acquisition started, Cy5-labelled anti-MMR Nbs were i.v. injected [experimental conditions: (m)anti-MMR, (biv)anti-MMR or un-(biv)anti-MMR + (m)anti-MMR, with un-(biv)anti-MMR Nbs injected 1 hour before the administration of Cy5-labelled-(m)anti-MMR Nbs] and the signal was collected over time (Figure 3A and Movie S4, Movie S5 and Movie S6 for healthy tissue; Figure 4A and Movie S7, Movie S8 and Movie S9 for tumor tissue). The gene discussed is MRC1; the disease is neoplasm.