IF analysis showed that IPI-504 remarkably diminished the aggregated mutant p53 protein in 4T1-BAG2-trp53R172H tumors, while there was no p53 aggregation in 4T1-BAG2-trp53R172H-I252R and 4T1-trp53R172H-shBAG2 tumor sections (Figure 6E and Figure S6B-C). The gene discussed is TP53; the disease is neoplasm.