The functional annotations of these subnetworks include peptide ligand-binding receptors, Gα signaling events, positive regulation of nitric-oxide synthase biosynthetic process, DTX3L-PARP9-STAT1 complex, immune response-activating signal transduction, immune response-regulating signaling pathway, and integrin MAPK1 signal transduction connection, of which STAT1 and MAPK1 were highly related to cancer, and others were related to metabolism and microenvironment, as shown in Figure 6. This evidence concerns the gene DTX3L and cancer.