AKT1 and early-onset autosomal dominant Alzheimer disease: KEGG enrichment pathway analysis revealed that neuroactive ligand-receptor interaction [48], PI3K-AKT signaling pathway [49], cholinergic synapse [50], regulation of actin cytoskeleton [51], Alzheimer's disease, pathways of neurodegeneration-multiple diseases, MAPK signaling pathway [52], and cGMP-PKG signaling pathway [53] are important pathways related to disease regulation in AD and have been reported in the literature, suggesting that the pathways predicted to be enriched in this study have high confidence.