BACE1 and Alzheimer disease: The neuroprotective effects of Quercetin have multiple mechanisms, including inhibition of Aβ aggregation [20], inhibition of NFT formation, inhibition of amyloid precursor protein (APP) cleavage enzyme (BACE1) inhibition [21], and acetylcholinesterase (AChE) inhibition [22] to reduce oxidative stress in AD [23].