KEGG enrichment pathway analysis revealed that neuroactive ligand-receptor interaction [48], PI3K-AKT signaling pathway [49], cholinergic synapse [50], regulation of actin cytoskeleton [51], Alzheimer's disease, pathways of neurodegeneration-multiple diseases, MAPK signaling pathway [52], and cGMP-PKG signaling pathway [53] are important pathways related to disease regulation in AD and have been reported in the literature, suggesting that the pathways predicted to be enriched in this study have high confidence. Here, AKT1 is linked to Alzheimer disease.