Hyperammonemia also reduced the total content (82 ± 3%, p < 0.05) (Fig. 11E) and membrane expression (54 ± 6%, p < 0.0001) (Fig. 11F) of the TGFβ receptor 2, which were also normalized by treatment with EVs from MSCs (104 ± 6%, p < 0.01; and 119 ± 10%, p < 0.0001, respectively) or with recombinant TGFβ (107 ± 6%, p < 0.01; and 105 ± 2%, p < 0.0001, respectively) but not by EVs in the presence of anti-TGFβ (78 ± 7%, p < 0.01; and 73 ± 6%, p < 0.0001, respectively) or by EVs lacking TGFβ (83 ± 3%, p < 0.05; and 60 ± 7%, p < 0.0001, respectively) (Fig. 11E, F). This evidence concerns the gene TGFB1 and Hyperammonemia.