Regarding the metabolic interplay between adipocytes and ATMs in the TME, adipocytes overexpress fatty acid binding protein 4, which promotes lipid transfer from adipocytes to macrophages and activates IL-6/STAT3 signaling through upregulation of the NF-κB/miR-29b pathway, thereby enhancing tumor proliferation and invasiveness [149]. This evidence concerns the gene STAT3 and neoplasm.