In present study, we found HMOX1 and STAT3 were significantly higher in pulp of Inflamed group than that of normal group, and lower in pulp of iRoot group than that of Inflamed group, which indicated that HMOX1 and STAT3 are important inflammation factors in pulpitis, and the expression level of them could be reversed by vital pulp treatment. Here, STAT3 is linked to pulpitis.