KNL1 and neoplasm: ZNF165 (C2H2 zinc finger transcription factor, also known as CT53) regulates the expression of genes in TGFβ pathway to promote tumorigenesis [38, 39]; TEX14, CASC5, TTK, and NUF2 all participate in the kinetochore assembly process of tumor cells [40, 41]; MAGE-A3/6 interacts with TRIM28 to regulate the proteasome-dependent degradation of tumor suppressors [30, 42].