PRM1 and colorectal carcinoma: After well matched for age and gender, we found that higher levels of serum PRM1 were observed in CRC patients than that in healthy controls (HCs) from both cohorts: 814.03 ± 625.37 vs 96.17 ± 88.53 pg/mL in test cohort (P < 0.001; Fig. 2f), and 577.5.35 ± 486.78 vs 179.79 ± 92.48 pg/mL in validation cohort (P < 0.001; Fig. 2i).