Moreover, after applying a Bonferroni correction to account for multiple comparisons (Fig. 5d, light blue line), 10 characteristics remained statistically at P < 0.000794 (where 0.000794 equals 0.05/64) which includes: the mitral regurgitation grade, LV end-diastolic volume, left atrium (LA) dimension, LV end-systolic volume, interventricular septal dimension, prescription of an ACEI or ARB, prescription of digoxin, systolic blood pressure, NT-proBNP and prescription of a diuretic. The gene discussed is NPPB; the disease is Mitral regurgitation.