DDX17 and colorectal carcinoma: To uncover the underlying mechanisms by which the DDX17/miR-149-3p axis controls CRC metastasis, we carried out RNA sequencing and analyzed the downregulated genes triggered by DDX17 with a criterion of 1.5-fold change and adjusted p value < 0.05 (Supplementary Tables S2, S3) as well as the predicted targets of miR-149-3p by the TargetScan database.