Moreover, LncRNA-PAX8-AS1 rs4848320 and rs1110839 as well as LAIR-2 rs2287828 were functionally correlated with the serum expression levels of LncRNA-PAX8-AS1 and LAIR-2 mRNA along with its protein, respectively in hypothyroidism. The gene discussed is LAIR2; the disease is hypothyroidism.