For rs4848320 (C/T) and rs1110839 (G/T) in the LncRNA-PAX8-AS1 gene, the minor T allele was associated with increased risk of clinical hypothyroidism (adjusted OR = 2.01, P = 0.0015 and 2.2, P < 0.0001, respectively) with adjustment for age and sex as confounding factors (Table 2). This evidence concerns the gene PAX8 and hypothyroidism.