Surprisingly, the literature on LncRNA-PAX8-AS1 rs4848320 and rs1110839 showed a variety of approaches; in a Southeast Iranian population, the T allele carriers in LncRNA-PAX8-AS1 rs4848320 increased the susceptibility of developing childhood acute lymphocytic leukemia, while rs1110839 variant has no effect19. This evidence concerns the gene PAX8 and acute lymphoblastic leukemia.