Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R), serotonin 2C (5-HT2CR), and melanocortin4 (MC4R), which all reduce body weight primarily by suppressing food intake. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.