Kv3.1/3.2 channels are highly expressed on parvalbumin interneurons,60,99,100 where they are responsible for allowing such neurons to propagate action potentials at the high rates seen during gamma frequency activity.62, , –65 Furthermore a Kv3.1 knockout model showed increased gamma power101 and unmedicated patients with schizophrenia are known to have reduced Kv3.1 expression,102 and increased resting gamma power.49 Thus, the action of AUT00206 on Kv3.1/3.2 channels could explain our finding that AUT00206 reduces frontal power in the disorder. This evidence concerns the gene KCNC1 and schizophrenia.