Similar to GBP2/5, MARCH8, and α-SNAP blocking role on viral infection by targeting furin [13–15], it is rational to deduce that PAR1 probably restricts infection of a broad spectrum of enveloped viruses, other than hMPV and HIV-1 [16,56,57], whose envelope glycoproteins depend on furin cleavage. Here, MARCHF8 is linked to viral infectious disease.