Our results support that FOXM1 can directly increase CXCR4 expression in CRC cells by binding to the promoter of CXCR4. Hence, FOXM1 and CXCL12/CXCR4 may form a positive feedback loop in the CRCLM; however, this hypothesis requires further investigation. The gene discussed is CXCL12; the disease is colorectal carcinoma.