CDH1 and eosinophilic esophagitis: Likewise, although soluble E-Cadherin has been shown to be increased in cells undergoing EMT (35, 36) and EMT has been associated with both EoE- and age-associated fibrosis (10, 11, 13, 37), addition of soluble E-Cadherin to culture medium in FEF3 fibroblast contraction assays did not effect contractility.