While dose response experiments are necessary to more thoroughly examine these factors as mediators of age-associated fibrosis, neither Periostin nor soluble E-Cadherin was found to show significant differential expression in our cytokine array experiments comparing expression of 200 soluble factors in esophageal epithelium-enriched tissue fractions in young and aged mice (Supplementary File S1). The gene discussed is CDH1; the disease is fibrosis.