GPX4 and triple-negative breast carcinoma: Figure 5 demonstrates that lipid peroxidation increased after 6 h of exposure to both IC50 and IC90 doses in HepG2 cells. Elevated lipid peroxidation is a notable mechanism that initiates the form of cell death known as ferroptosis. Similar to what was recently discovered in triple-negative breast cancer cells (Ding et al., 2021), Figure 6 demonstrates that in HepG2 cells, GPx4 protein levels were significantly decreased but only at the IC90 dose after 24 h.