We then further explored the expression of these genes between LN+ and LN- BLCA patients, which showed that the expression level of AZGP1, C11orf86, HSD17B2, and SHH in LN+ patients were significantly lower than in LN- patients, meanwhile, CLIC3 and KCNK13 were both highly expressed in LN+ patients. The gene discussed is CLIC3; the disease is bladder transitional cell carcinoma.