In the present study, we focused on stromal cells of TME and tried to establish a nomogram combining an StrLNM signature for preoperatively predict LNM and confirmed that AZGP1, C11orf86, CLIC3, HSD17B2, KCNK13, and SHH were potentially predictive biomarkers in BLCA. This evidence concerns the gene SHH and bladder transitional cell carcinoma.