Moreover, we found the expression levels of AZGP1, C11orf86, HSD17B2, SHH, CLIC3, and KCNK13 were significantly different between our own BLCA patients’ tumor and para-carcinoma tissues using qPCR, and the expression level of AZGP1, C11orf86, HSD17B2 and SHH in LN+ patients were significantly lower which indicates they all had a positive effect on patients’ prognosis. The gene discussed is HSD17B2; the disease is carcinoma.