In the present study, we focused on stromal cells of TME and tried to establish a nomogram combining an StrLNM signature for preoperatively predict LNM and confirmed that AZGP1, C11orf86, CLIC3, HSD17B2, KCNK13, and SHH were potentially predictive biomarkers in BLCA. The gene discussed is CLIC3; the disease is bladder transitional cell carcinoma.