The activation of REG3A will enhance the JAK2/STAT3 pathway and form a positive feedback loop of REG3A-JAK2/STAT3, thereby amplifying the carcinogenic effect of IL-6/JAK2/STAT3, and ultimately leads to excessive PC cell proliferation in vitro and in vivo and tumor formation (5). This evidence concerns the gene STAT3 and pachyonychia congenita.