AKR1C3 and in situ carcinoma: The mRNA and protein levels of AKR1C3 in CRPC tumors and metastatic tissues were significantly higher than those in normal prostate tissues and carcinoma in situ (23, 24).The high expression of AKR1C3 in tumor tissues is associated with accelerated the progression and metastasis of PCa, and its downregulation can inhibit the growth and invasion of PCa cells.