Disease-free survival analysis (Figure 1B) showed that the survival rate of PCa patients with high AKR1C3 expression (red curve) was lower than that of PCa patients with low AKR1C3 expression (blue curve) (P<0.05), AKR1C3 was regarded as a gene for adaptive changes in PCa cells after ADT. The gene discussed is AKR1C3; the disease is posterior cortical atrophy.