Some somatic variants of certain genes, including EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, ERBB2, NTRK, TP53, and PI3KCA, have been identified as common driver mutations in the NSCLC National Comprehensive Cancer Network (NCCN) guidelines (version 3.2022). The gene discussed is ROS1; the disease is non-small cell lung carcinoma.