Some somatic variants of certain genes, including EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, ERBB2, NTRK, TP53, and PI3KCA, have been identified as common driver mutations in the NSCLC National Comprehensive Cancer Network (NCCN) guidelines (version 3.2022). The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.