HK2 and neoplasm: Further, an increase in tumor growth and proliferation efficiency in OPM-BMG tumors (Figure 4) correlated well with the downregulation of activated AMPK (p-AMPK; Figures 6E, F) (43) coupled with HK-II, Glut-1, and PKM-2 (Figures 5B, C), leading to glycolytic up-regulation compared to its parental phenotype.