Further, the rapid tumor growth in OPM-BMG xenografts was associated with an increase in the expression of pro-angiogenesis factors like VEGF and MMP-9 (Figures 6A–C), suggestive of stimulated neovascularization (34, 35) that appears to be driven by the increased ROS generation (Figure 5A) (33). The gene discussed is MMP9; the disease is neoplasm.