TFAM and neoplasm: Additionally, in OPM-BMG tumors, the upregulated level of mitochondrial biogenesis regulatory proteins PGC-1α (~1.73 fold) and TFAM (~1.5 fold), compared to BMG-1 (Figures 5D, E), confirmed an increase in mitochondrial mass and the induction of mitochondrial biogenesis in OPM-BMG tumor tissue.