A significant up-regulation of HIF-1α, HK-II, and PKM2 in addition to ROS, as well as both the enhanced biogenesis transcription factors PGC-1α and TFAM, were observed in OPM-BMG compared to BMG-1 tumor (Figure 5) substantiates the impact of high glycolysis++ and OXPHOS++ in the higher invasive potential seen in these tumor-derived cells (Figures 6J, K). Here, HK2 is linked to neoplasm.