PIK3CA and cancer: Some examples of metabolic intervention tactics to improve immunotherapy response include: 1) PI3K-AKT-mTOR blockade which can simultaneously inhibit cancer metabolism and disinhibit the immune system via inhibition of regulatory T cells (38) and 2) targeting glutaminolysis via glutaminase (GLS) or arginase 1 to promote differentiation and function of CD4 and CD8 T cells (39–42).