NOTCH1 and adrenal cortex carcinoma: Renata Ferrarotto proposed in 2017 that patients with NOTCH1 mutations should be defined as a population with a poor prognosis who are prone to have extrapulmonary metastasis (14); In 2021, they proposed two risk subtypes defined by MYC and TP63: ACC-I (37%) and ACC-II (63%).