CD274 and gastric cancer: Although the underlying mechanisms remain poorly understood, Zhang and colleagues have recently started analyzing tumor-derived EVs induced N2 neutrophil polarization in gastric cancer, demonstrating that gastric cancer-derived EVs can induce the expression of programmed death-ligand 1 (PD-L1) on neutrophils, which in turn polarizes their differentiation through the N2 phenotype and suppresses T cell-mediated immunity (108, 109).