Starting from data showing that osteosarcoma tumor-secreted EVs can induce a pro-metastatic phenotype by strongly inducing IL-6 production in mesenchymal stem cells (MSCs), it has been demonstrated that EVs from aggressive cancer cell lines can induce MSCs to express inflammatory cytokines and chemokines, among which IL-8 was the most upregulated one, and that this was due to tumor EV-associated non-coding RNAs. This evidence concerns the gene IL6 and osteosarcoma.