CXCR2 and cancer: Tumor-derived EVs from a metastatic human melanoma cell line (MV3), for example, have been shown to induce neutrophil chemotaxis through the CXCR2/PI3K-Akt axis and to promote the formation of NETs (103) (Figure 1), which play a crucial role in inducing cancer-associated thrombosis (111–113) and tumor drug resistance (114).