CXCL8 and neoplasm: In this review, we will describe the role of IL-8 and EVs in the regulation and mediation of neutrophil biology and function in the TME, promoting pro-tumoral functions of these cells, ultimately leading to neutrophil-mediated tumor drug resistance through the production of neutrophil extracellular traps (NETs) and the secretion of neutrophil-derived EVs and other factors.