THBS1 and neoplasm: In tumors, NETs have been identified as factors that can significantly contribute to carcinogenesis and metastasis (11, 54) in several ways, as by inducing the degradation of the extracellular matrix which promotes the extravasation of cancer cells (50), trapping circulating tumor cells (CTCs) (55, 56) or deactivating thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis and tumor progression (57, 58).