EGF-displaying phages were then studied to observe their interaction and targeted effect within spheroids formed from HT-29 cells, human colon adenocarcinoma cells that we have studied extensively for their abilities to respond to anticancer drugs, natural products and mediators in the tumor microenvironment (22, 23, 25, 27, 96, 97) and which are known to overexpress EGFR (98, 99). This evidence concerns the gene EGFR and neoplasm.