Indeed, a recent study by Dong and colleagues where T1D patients were treated with autologous polyclonal Treg cells followed by one or two courses of low-dose IL-2 revealed that, while IL-2 increased the numbers of both infused and endogenous Treg cells, it also boosted subsets of NK cells and CD8+ T cells (84). The gene discussed is IL2; the disease is type 1 diabetes mellitus.