Whole blood transcriptomic approaches, based on signatures that primarily comprise interferon stimulated genes (ISG), are being developed for TB diagnosis, with promising strategies based on a 3-gene signature (Sweeney3 signature) in which a TB score is calculated using the formula (GBP5 + DUSP3)/2 – KLF2 (17), or the 11-gene blood TB risk signature, RISK11 (18). This evidence concerns the gene KLF2 and tuberculosis.