To better understand the drivers of IL-1ra secretion at baseline in TB, we performed correlation analysis of the protein data comprising 40 cytokines/chemokines in the Null tube and showed that the strongest association (r=0.52, p=0.0001) was with IL-8 (Figure 2C), a cytokine which also had significantly higher levels in TB patients (Figure 2D). Here, CXCL8 is linked to tuberculosis.