TLR7 and systemic lupus erythematosus: Both TLR and IL-1R family members drive MyD88-dependent inflammation, and TLR7 is a MyD88-dependent endosomal TLR that has been shown to be of critical importance in several autoimmune diseases (9–11), most notably Systemic Lupus Erythematosus (SLE) or lupus (12).