CD274 and non-small cell lung carcinoma: It is well known that NSCLC as a whole has higher PD-L1 expression and TMB relative to breast and gastric cancers, but the whole character could not accurately define the individuals, as EGFR-mutant NSCLC and triple-negative breast cancer (TNBC), which represented the different immunogenicity and generated an opposite immune response to ICIs (10, 35).