For the above researched cancers (BRCA, COAD, LUAD and KIRC), FBXWs as a whole showed a positive relationship, including FBXW1 and FBXW7 (sFigure 4) (These findings confirmed the synergistic relationships among FBXW members and revealed that the SCF complex may have a more competitive and complicated mechanism than we thought. Here, KITLG is linked to cancer.