S100A16 and cancer: 49 ECM gene signatures were found to be correlated with PLAU, of which three, namely, secreted factors S100A16 (cancer-cell–derived), ECM regulator PLOD2 (PSC-derived) and ECM regulator TGM2 (cancer and stromal cell-derived) were significantly associated with poor survival in the TCGA-PDAC cohort.