S100A16 and neoplasm: However, at the protein level (using the CPTAC-PDAC cohort), while PLOD2, S100A16 and TGM2 were all significantly differentially overexpressed in tumours compared to the normal adjacent pancreas (ST 15B), only upregulation of PLOD2 (log-rank test, P= 0.05) protein was found to be associated with poor survival (refer to PLOD2).