PLOD2 and cancer: Survival analysis of the TCGA-PDAC cohort revealed that secreted factor S100A16 (cancer-cell–derived), ECM regulator PLOD2 (stromal cell-derived) and ECM regulator TGM2 (derived from both cancer cells and stromal cells) genes were overexpressed in human PDAC and correlated with short patient survival (log-rank test, P < 0.05), Figures 7B–D.