Furthermore, immunostaining for the stem cell marker ALDH1A1, which plays a role in recurrence, metastasis, and treatment resistance, demonstrated that U10 significantly decreased ALDH1A1 expression compared to the mice treated with control and Gemcitabine alone (SF8A, B), suggesting that the uPA inhibition may inhibit cancer stemness. This evidence concerns the gene ALDH1A1 and cancer.