Interestingly, it was found that PLAU expression correlated directly with the activity of 11 KEGG pathways, including glycosaminoglycan biosynthesis - chondroitin sulfate, basal cell carcinoma, Hedgehog signalling pathway, axon guidance, pathways in cancer, pancreatic cancer, TGF-beta signalling pathway, arrhythmogenic right ventricular cardiomyopathy (ARVC), wnt signalling pathway, and renal cell carcinoma, FDR<0.01 (Figure 5A and ST 11A). This evidence concerns the gene PLAU and cancer.