EDN3 and cancer: These comprised 31 transcription factors (including CDX2, FOXA2, GATA6, HNF1A, HNF4A, PDX1, PPARGC1A, and TOX3), two cell differentiation markers (FUT4 and TNFRSF11A), 11 protein kinases (e.g. ACVR1B, ERBB3, FGFR4, HIPK2, KALRN, PKDCC, SCYL3), four translocated cancer genes (including PRDM16 and TMPRSS2), six oncogenes (including MYCN, CEBPA, and MECOM), one tumour suppressor gene (HNF1A) and four cytokines and growth factors (including FAM3B, EDN3, SEMA4G, and FAM3D, ST 6A).