With a higher immune and stromal score, dHGP liver metastases were characterized by a higher abundance of monocytes, fibroblasts, M2 macrophages, CD8+ T cells, and naive B cells and obtained higher scores from 7 immune-related signatures, indicating that the TIME had a better anti-tumor ability (Wilcoxon test, p < 0·05; Tables S6, S7; Figure 2E). This evidence concerns the gene CD8A and neoplasm.