KRAS and cancer: Furthermore, comparisons of the HALLMARK pathways activity indicated that dHGP liver metastatic lesions were significantly enriched in specific cancer-related pathways, including epithelial-mesenchymal transition (EMT), angiogenesis, KRAS signaling pathway, inflammatory response, and interferon-gamma response, while the rHGP liver metastatic lesions were associated with DNA repair, fatty acid metabolism, E2F targets, oxidative phosphorylation, G2M checkpoints, glycolysis and MYC target (Wilcoxon test, p < 0·05; Tables S4, S5; Figure 2D).