LRG1 and arthritic joint disease: Since our aim was to propose disease markers that could potentially indicate arthritis severity, we selected the top three upregulated genes in CIA, namely Lrg1, Cd38 and F11r. As expected, qPCR showed that these genes were significantly overexpressed in the CCR2hi OCP subset of CIA compared to CTRL mice, but, in addition, they were also increased in the CCR2lo OCP subset of CIA compared to CTRL mice, although at a much lower level of expression.