TLR-stimulated macrophages from ITGAM SNP carriers with systemic lupus erythematosus showed increased basal expression of IRF7 and IFN-β (66), whereas activation of CD11b inhibited the LPS-induced pro-inflammatory response in macrophages of mice with endotoxic shock (67). The gene discussed is ITGAM; the disease is systemic lupus erythematosus.