The expression level of genes from the osteoclast differentiation pathway in the CCR2hi subset from CIA group remained high (Fcgr1), or even increased (Socs3) at day 2 osteoclastogenic culture compared to non-cultured counterparts (day 0), confirming their role in osteoclastogenic potential in arthritis (Figure 7B). Here, FCGR1A is linked to arthritic joint disease.