When the profile of CD4+ T cell subsets in the spleen and draining lymph node (dLN) of the psoriasis animal model was examined, the high level of T-bet+ or IFN-γ+ CD4+ T cells and ROR-γt+ or IL-17A+ CD4+ T cells was detected in psoriasis-induced mice (Figures 5A-D). The gene discussed is CD4; the disease is psoriasis.