CD4 and psoriasis: Since Th1 cells and Th17 cells are the critical factors for psoriasis pathogenesis and ndSTAT1-TMD inhibited the functions and differentiation program of both Th1 and Th17 cells in vitro and in vivo (38, 39), we hypothesized that ndSTAT1-TMD treatment of psoriasis animal model changes the functional status of CD4+ T cell subsets in vivo.