The proportions of Tregs CD4+CD8+FOXP3+ (p = 0.0056), M1 macrophages CD11b+CD86+ (p = 0.0017), and M2 macrophages CD11b+CD206+ (p = 0.0393) in CRC model mice were higher than those in the control group. The gene discussed is CD4; the disease is colorectal carcinoma.