The proportions of B cells CD19+ (p = 0.0090) and memory B cells CD19CD27+ (p = 0.0430) in the CRC group were significantly lower, whereas helper T lymphocyte CD4+ and cytotoxic T lymphocyte CD8+ cells in the CRC group tended to be lower than those in the control group. The gene discussed is CD19; the disease is colorectal carcinoma.