Even though the effect of DHF on predicted target using computational approach seems promising, further studies are required to test the effect of DHF clinically for proposed activity against inflammatory EoE as well as the detailed mechanism of action on how these genes and targets interact with primary drivers of EoE, including Th2 genes- IL-4, IL-5, and IL-13 needs to be studied. The gene discussed is IL5; the disease is eosinophilic esophagitis.