For example, high expression of ADAMTS8 was associated with better survival in patients with lung cancer by inhibiting cell proliferation and promoting apoptosis.ADAMTS8 overexpression was also associated with decreased levels of vascular endothelial growth factor A (VEGFA), which is a major regulator of angiogenesis and contributes to tumor growth and metastasis (99). This evidence concerns the gene VEGFA and neoplasm.