The link between HCMV infection and cardiovascular disease is further supported by the association between expansions of T cell differentiated CD28 null populations in HCMV positive donors with vascular damage (43); and T cells expressing the fractalkine receptor CX3CR1 are enriched among HCMV specific T cells and can home to vascular endothelium (44). The gene discussed is CX3CR1; the disease is cytomegalovirus infection.