Combining PET/CT imaging with scRNA-seq of granuloma cells obtained from individual lesions formed early (detected at 4 weeks post-infection) or late (detected at 10 weeks post-infection) revealed that early-appearing, high-burden granulomas were characterized by a type 2 wound healing response driven by IL-4 and IL-13 producing cells and transcripts implicated in fibrosis, TGF-β signaling and tissue remodeling (146). The gene discussed is TGFB1; the disease is Granuloma.