Other studies have shown that depletion of CD25-postive Treg cells in TB infected mice did not alter the course of infection (67, 68), while depletion of FoxP3-postive Treg cells was shown to ameliorate TB disease (69) and adoptive transfer of CD25+FoxP3+ Treg cells prevented effective CD4+ T cells responses and bacterial clearance (70). Here, CD4 is linked to infection.