Furthermore, scRNA-seq and mass cytometry analyses of immune cells in another non-human primate model of latent versus active TB infection demonstrated that increased lung as well as circulating NK cells expressed cytolytic effectors, including perforin, granzymes and granulysin, which suggest a key protective role for NK-cell mediated cytotoxicity during TB latency in the lung compartment (129). Here, PRF1 is linked to tuberculosis.