Instead, late-appearing, low-bacterial-burden granulomas were associated with a type 1 response and a higher proportion of a cytotoxic subcluster consisting of conventional αβ CD8+ T cells that expressed genes encoding different effector molecules and functions including perforin and granzymes as well as other genes relevant for motility, migration, tissue residency (CX3CR1, TGFBR3, and S100A10), and regulators of cell state (AHNAK, KLF3, and ZEB2) (146). The gene discussed is CD8A; the disease is Granuloma.